Division of General Surgery

Christopher Mantyh, MD

Associate Professor of Surgery

Chief, Gastrointestinal and Colorectal Surgery

Department:
Surgery

Division:
General Surgery

Mailing Address:
DUMC 3117 Durham, NC 27710

Telephone:
919-684-4064

Office Telephone:
919-681-3977

Fax:
919-681-7934

Training:
MD, University of Wisconsin School of Medicine and Public Health, 1991

Fellowship:
Colorectal Surgery, Cleveland Clinic Foundation (Ohio), 1998-1999

Residency:
General Surgery, Duke University Medical Center, 1991-1998

Clinical Interests:
Colorectal surgery, surgery for inflammatory bowel disease, benign anal rectal surgery, sphincter-saving procedures for rectal cancer, fecal incontinence surgery, rectal prolapse repair, familial polyposis surgery, laparoscopic colon surgery, diverticulitis, anal cancer, Crohn's disease, ulcerative colitis, ileus, motility, neurogenic inflammation

Research Interests:
Neurogenic inflammation
Ulcerative colitis
Crohn's disease
Neuropeptides
Receptors
Vanilloid receptor
Substance P
Intestinal motility
Colorectal cancer outcomes

Publications:
de la Fuente SG, Ludwig KA, Mantyh CR. Preoperative immune status determines anal condyloma recurrence after surgical excision. Dis Colon Rectum. 2003 Mar;46(3):367-73.

de la Fuente SG, Levin LS, Reynolds JD, Olivares C, Pappas TN, Ludwig KA, Mantyh CR. Elective stoma construction improves outcomes in medically intractable pressure ulcers. Dis Colon Rectum. 2003 Nov;46(11):1525-30.

de la Fuente SG, Gottfried MR, Lawson DC, Harris MB, Mantyh CR, Pappas TN. Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. J Gastrointest Surg. 2003 Jan;7(1):96-101.

Kihara N, de la Fuente SG, Fujino K, Takahashi T, Pappas TN, Mantyh CR. Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. Gut. 2003 May;52(5):713-9.

Kalady MF, Fields RC, Klein S, Nielsen KC, Mantyh CR, Ludwig KA, Nielson KC. Loop ileostomy closure at an ambulatory surgery facility: a safe and cost-effective alternative to routine hospitalization. Dis Colon Rectum. 2003 Apr;46(4):486-90.

Onaitis, M.W., Noone, R.B., Hurwitz, H., Morse, M., Jowell, P., McGrath, K., Lee, C, Anscher, M.S., Clary, B., Mantyh, C., Pappas, T., Ludwig, K., Seigler, H., Tyler, D.  Neoadjuvant chemoradiation for rectal cancer: analysis of clinical outcomes from a 13-year institutional experience. Ann Surg. 233:778-785, 2001.

Onaitis, M.W., Noone, R.B., Fields, R., Hurwitz, H., Morse, M., Jowell, P., McGrath, K., Lee, C, Anscher, M.S., Clary, B., Mantyh, C., Pappas, T., Ludwig, K., Seigler, H., Tyler, D.  Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival.  Ann Surg Oncology, 8:801-806, 2001.

Mantyh CR, Hull TL, Fazio VW. Coloplasty in low colorectal anastomosis: manometric and functional comparison with straight and colonic J-pouch anastomosis. Dis Colon Rectum. 2001 Jan;44(1):37-42.

Mantyh CR, McVey DC, Vigna SR. Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats. Neurosci Lett. 2000 Oct 6;292(2):95-8.

Fazio VW, Mantyh CR, Hull TL. Colonic "coloplasty": novel technique to enhance low colorectal or coloanal anastomosis. Dis Colon Rectum. 2000 Oct;43(10):1448-50.

Mantyh PW, Rogers SD, Ghilardi JR, Maggio JE, Mantyh CR, Vigna SR. Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo. Brain Res. 1996 May 6;719(1-2):8-13.

Mantyh CR, Pappas TN, Lapp JA, Washington MK, Neville LM, Ghilardi JR, Rogers SD, Mantyh PW, Vigna SR. Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology. 1996 Nov;111(5):1272-80.

Mantyh CR, Maggio JE, Mantyh PW, Vigna SR, Pappas TN. Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis. Dig Dis Sci. 1996 Mar;41(3):614-20.

Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science. 1995 Jun 16;268(5217):1629-32.

Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE. Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2622-6.

Mantyh CR, Vigna SR, Bollinger RR, Mantyh PW, Maggio JE, Pappas TN. Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Gastroenterology. 1995 Sep;109(3):850-60.

Mantyh CR, Vigna SR, Maggio JE, Mantyh PW, Bollinger RR, Pappas TN. Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neurosci Lett. 1994 Sep 12;178(2):255-9.

Mantyh CR, Pappas TN, Vigna SR. Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. Gastroenterology. 1994 Oct;107(4):1019-30.

Lawson DC, Mantyh CR, Pappas TN. Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog. Dig Dis Sci. 1994 Jul;39(7):1405-8.

Kilgore WR, Mantyh PW, Mantyh CR, McVey DC, Vigna SR. Bombesin/GRP-preferring and neuromedin B-preferring receptors in the rat urogenital system. Neuropeptides. 1993 Jan;24(1):43-52.

Zimmerman RP, Gates TS, Mantyh CR, Vigna SR, Welton ML, Passaro EP Jr, Mantyh PW. Vasoactive intestinal polypeptide receptor binding sites in the human gastrointestinal tract: localization by autoradiography. Neuroscience. 1989;31(3):771-83.

Vigna SR, Mantyh CR, Soll AH, Maggio JE, Mantyh PW. Substance P receptors on canine chief cells: localization, characterization, and function. J Neurosci. 1989 Aug;9(8):2878-86.

Mantyh PW, Gates T, Mantyh CR, Maggio JE. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. J Neurosci. 1989 Jan;9(1):258-79.

Gates TS, Zimmerman RP, Mantyh CR, Vigna SR, Mantyh PW. Calcitonin gene-related peptide-alpha receptor binding sites in the gastrointestinal tract. Neuroscience. 1989;31(3):757-70.

Bacay AC, Mantyh CR, Cohen AH, Mantyh PW, Fine LG. Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies. Am J Kidney Dis. 1989 Nov;14(5):386-95.

Zimmerman RP, Gates TS, Mantyh CR, Vigna SR, Boehmer CG, Mantyh PW. Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract. Peptides. 1988 Nov-Dec;9(6):1241-53.

Popper P, Mantyh CR, Vigna SR, Maggio JE, Mantyh PW. The localization of sensory nerve fibers and receptor binding sites for sensory neuropeptides in canine mesenteric lymph nodes. Peptides. 1988 Mar-Apr;9(2):257-67.

Mantyh PW, Mantyh CR, Gates T, Vigna SR, Maggio JE. Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease. Neuroscience. 1988 Jun;25(3):817-37.

Mantyh CR, Gates TS, Zimmerman RP, Welton ML, Passaro EP Jr, Vigna SR, Maggio JE, Kruger L, Mantyh PW. Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proc Natl Acad Sci U S A. 1988 May;85(9):3235-9.

Kruger L, Mantyh PW, Sternini C, Brecha NC, Mantyh CR. Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites. Brain Res. 1988 Nov 1;463(2):223-44.

Gates TS, Zimmerman RP, Mantyh CR, Vigna SR, Maggio JE, Welton ML, Passaro EP Jr, Mantyh PW. Substance P and substance K receptor binding sites in the human gastrointestinal tract: localization by autoradiography. Peptides. 1988 Nov-Dec;9(6):1207-19.

Bacay AC, Mantyh CR, Vigna SR, Mantyh PW. Receptor binding sites for atrial natriuretic factor are expressed by brown adipose tissue. Peptides. 1988 Sep-Oct;9(5):1021-6.

Vigna SR, Mantyh CR, Giraud AS, Soll AH, Walsh JH, Mantyh PW. Localization of specific binding sites for bombesin in the canine gastrointestinal tract. Gastroenterology. 1987 Dec;93(6):1287-95.

Mantyh CR, Kruger L, Brecha NC, Mantyh PW. Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human. Brain Res. 1987 Jun 2;412(2):329-42.

Akesson TR, Mantyh PW, Mantyh CR, Matt DW, Micevych PE. Estrous cyclicity of 125I-cholecystokinin octapeptide binding in the ventromedial hypothalamic nucleus. Evidence for downmodulation by estrogen. Neuroendocrinology. 1987 Apr;45(4):257-62.

Mantyh CR, Kruger L, Brecha NC, Mantyh PW. Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human. Hypertension. 1986 Aug;8(8):712-21.

Mantyh CR, Mantyh PW. Differential localization of cholecystokinin-8 binding sites in the rat vs. the guinea pig brain. Eur J Pharmacol. 1985 Jul 11;113(1):137-9.

Mantyh CR, Brecha NC, Soon-Shiong P, Mantyh PW. Specific binding sites for atrial natriuretic factor in the human kidney. N Engl J Med. 1985 Jun 27;312(26):1710.