Division of General Surgery

Bradley H. Collins, MD

Associate Professor of Surgery

Department:
Surgery

Division:
General Surgery

Mailing Address:
DUMC 3512 Durham, NC 27710

Telephone:
919-681-3855

Office Telephone:
919-681-3855

Fax:
919-684-8716

Training:
MD, Duke University School of Medicine, 1989

Fellowship:
Transplant Surgery, University of Wisconsin at Madison, 1997-1999

Residency:
General Surgery, Duke University Medical Center, 1989-1997

Clinical Interests:
Liver, pancreas, and kidney transplantation; general surgery in transplant patients; dialysis access surgery

Research Interests:
(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus.  There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States.  The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient.  In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression.  Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver.  The project is a collaborative effort with hepatologist Dr. Don Rockey.  We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes.  FACS technology is used to identified the lymphocyte populations and then sort them.  The cytokine profile is then elucidated.  We plan to use gene chip technology to assess the gene expression.

Publications:
Couri CJ, Maze GI, Hinkson DW, Collins BH 3rd, Dawson DV. Medical grade calcium sulfate hemihydrate versus expanded polytetrafluoroethylene in the treatment of mandibular class II furcations. J Periodontol. 2002 Nov;73(11):1352-9.

Kendall WF Jr, Collins BH, Opara EC. Islet cell transplantation for the treatment of diabetes mellitus. Expert Opin Biol Ther. 2001 Jan;1(1):109-19.

Collins BH. Porcine islets as an alternative to human islets for transplantation. J Investig Med. 2001 Nov;49(6):576-9.

Collins BH, Horská A, Hotten PM, Riddoch C, Collins AR. Kiwifruit protects against oxidative DNA damage in human cells and in vitro. Nutr Cancer. 2001;39(1):148-53.

Ching CD, Harland RC, Collins BH, Kendall W, Hobbs H, Opara EC. A reliable method for isolation of viable porcine islet cells. Arch Surg. 2001 Mar;136(3):276-9.

6. Kendall WF, Collins BH. Ascites. In: Pappas TN and Purcell GP, eds. Unbound Surgery. Unbound Medicine (in press).

5. Collins BH. Rejection of the liver graft. In: Killengberg PG and Clavien P-A, eds. Medical Care of the Liver Transplant Patient. Blackwell Science, 2001:183-197.

4. Collins BH, Levin LS. Limb transplantation. Plastic and Reconstructive Surgery (in press).

3. Collins BH. Porcine islets as an alternative to human islets for transplantation. Journal of Investigative Medicine 2001; 49: Suppl.

2. Ching CD, Harland RC, Collins BH, Kendall WF, Hobbs HA, Opara EC. A reliable method for isolation of viable porcine islets. Archives of Surgery 2001; 136:276-279.

1. Kendall WF, Collins BH, Opara EC. Islet cell transplantation for the treatment of diabetes mellitus. Expert Opinion on Biological Therapy 2001; 1:109-119.

(4) Collins BH. Porcine islets as an alternative to human islets for transplantation. Journal of Investigative Medicine 2001; 49: Suppl.

(3) Ching CD, Harland RC, Collins BH, Kendall WF, Hobbs HA, Opara EC. A reliable method for isolation of viable porcine islets. Archives of Surgery 2001; 136:276-279.

(2) Kendall WF, Collins BH, Opara EC. Islet cell transplantation for the treatment of diabetes mellitus. Expert Opinion on Biological Therapy 2001; 1:109-119.